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When the Syndicate formed in 1973 to work with the aliens, the aliens decided to take a family member from each main Syndicate family as "collateral". William Mulder discussed it with his wife Teena, but she was unable to make a choice. William later chose Fox, but that decision was superseded by the Cigarette Smoking Man who forced them to choose Samantha instead. — (Paper Clip, Demons)
- Many of the flashbacks seen in "Demons" were delusions of Fox Mulder, and the Cigarette Smoking Man may not have actually been involved in the choice, as he disputes involvement in "One Son".
On November 27, 1973, Samantha was eight and her brother was twelve. At 8:53 pm that evening, Samantha was playing a losing game of Stratego against her brother, while both children were lying on the floor of their family living room and their parents were visiting the Galbrands. Samantha had been permitted by their parents to watch a Western movie but they had left her brother in charge. Immediately after Samantha's brother captured one of her Stratego pieces, the two children began arguing about the television, with Samantha demanding to watch the Western movie even though her brother insisted that a news report regarding the Watergate scandal remain on the television as he was waiting for The Magician to start at 9:00 pm. She changed the channel but her brother reset it. In frustration, Samantha screamed for effect at her brother, who assertively reiterated that he would be watching The Magician and then started to walk away from both her and the television.
Samantha Mulder's abduction
When the lights and television in their living room suddenly lost power, Samantha looked at her brother as he accusingly told her that a fuse had blown. She fearfully cried out his name when an eerie hum, electrical and engine-like, began outside and objects in the room, including the Stratego pieces, started to shudder. They both looked towards the window, where strange, strobing red, orange and blue lights began to flash and fill the room. While Samantha's brother was distracted by the sight of a seemingly alien figure that appeared through a doorway that opened, she was apparently lifted off her feet and enveloped by a tube of yellow light that continued to levitate her still body in mid-air, turned face upwards, as it slowly carried her through the window without breaking the glass and up into the sky where she entered into an alien spacecraft, never to be seen again.
Samantha's abduction in 1973.
Her brother tried to obtain a gun from a hidden case in the room, while she was floating through the air, but, despite his best efforts, he could not save his sister and, having earlier told her to "get out of [his] life" during their heated argument, he was left calling after her, moments before a white light engulfed the area. — (Little Green Men).
Following this incident, Samantha was cloned several times. — (End Game)
No notes, phone calls or evidence of anything was found, at this time. There were no facts to confirm and nothing to offer any hope. The fact that she could not be found ultimately tore the Mulder family apart and no-one would talk about her disappearance — (Pilot). Additionally, Samantha's mother subsequently had many sleepless nights. — (Colony)
After her abduction, a huge investigation was organized in an attempt to find Samantha, using William Mulder's contacts in Washington. The investigation even went as far as to involve the Treasury Department. The search was called off by the Cigarette Smoking Man. — (Closure)