|My Struggle II||Credits||Gallery||Transcript|
The investigations that Mulder and Scully previously began with conspiracy theorist and web-TV show host Tad O’Malley (guest star Joel McHale) seem to have awakened powerful enemies. A widespread panic begins as people all over the country suddenly start falling gravely ill, and Scully must look within to try and find a cure. Meanwhile, Mulder confronts the man whom he believes to be behind it all, but another figure from Mulder and Scully’s past shows up.
My name is Dana Katherine Scully. I am a special agent with the Federal Bureau of Investigation, a career I chose after medical school, which promised a chance to further my aim as a scientist and as a seeker of justice in a science-based world. Soon after joining the FBI, I was asked to review the work of a fellow agent, Fox Mulder, and to debunk the X-Files, cases involving what my superiors regarded as science fiction and a waste of resources.
I quickly came to understand Mulder's work on the paranormal wasn't such as I'd been led to believe, that the X-Files were worthy of Mulder's investigations and of mine, that a world existed on the far fringes of accepted science, a world where a scientist would have her strongly held beliefs tested and retested. I would also come to fear that the institution I'd joined and invested with my trust was subject to the influence of dark forces outside the Bureau and sometimes within, forces threatened by Mulder's work and increasingly by mine. Shortly after sensing these threats, I was abducted from my home by unknown assailants and returned without a clear understanding why. But intervening incidents have led me to believe that during my short disappearance, I was subjected to tests, tests resulting in a life-threatening disease, its cure as mysterious as the illness itself, tests which I now suspect are part of a larger conspiracy, a conspiracy of men hiding science for almost 60 years...
....secrets kept from the American people by a self-interested cabal intent on the consolidation of power both at home and on a perilously global scale. But questions remain unanswered about their motives and their final objectives, when and where these men might play out their dark plans, and the significance of a recent test result of my personal genetic makeup turning up DNA anomalies that I can only classify... as alien.
-Dana Scully opening voice-over.
Six weeks after the events of "My Struggle" Scully arrives at FBI headquarters to find that Mulder has disappeared after watching an excerpt from Tad O'Malley's online news broadcast (which had been revived after being shut down prior). As Scully informs Skinner and Einstein of Mulder's absence, Mulder attempts to leave Washington—visibly unwell, and badly bruised.
Back in Washington, D.C., Scully receives a phone-call from O'Malley, who has arrived at Mulder's house for a pre-arranged meeting to discover that there are signs of a struggle. O'Malley explains that he suspects alien DNA has been injected into every American citizen in order to facilitate the widespread outbreak of a contagion, the Spartan Virus. Designed to strip humans of their immune systems, this contagion quickly begins to manifest itself nationwide, with Scully and Einstein noting a sharp increase in patients admitted to hospitals and triage centers.
Miller, finding a phone-tracking app on Mulder's computer, notes his position at Spartanburg, South Carolina, and leaves Washington in order to track him down, while Einstein questions Scully's medical theories. Scully, accepting that Einstein's doubts may be correct, receives a phone-call from former X-Files agent Monica Reyes (Annabeth Gish), who asks to meet, claiming to know how to develop a vaccine.
Act TwoDuring their meeting, Reyes reveals that, shortly after the closure of the X-Files, she was contacted by the badly injured Cigarette Smoking Man, who had survived the confrontation in New Mexico. Cigarette Smoking Man offers to secure both Scully and Reyes a place among the designated survivors of end-times, in exchange for Reyes' assistance in the colonization effort. Reyes departs the FBI shortly thereafter, and is absent when Scully "looks her up" in 2015. Reyes also reveals that she has spent the last twelve years assisting Cigarette Smoking Man, but with the intent to halt the invasion from within the Syndicate.
Scully and Einstein attempt to develop a vaccine using Scully's DNA, as Scully realizes that it is a combination of the alien genomes that remained after she was abducted and tested on, and the DNA anomalies instilled within her at the request of Reyes, that are protecting her from the contagion. It is the absence of alien DNA that is making everybody else susceptible. Mulder, meanwhile, approaches Cigarette Smoking Man, who offers him a chance to survive the outbreak. He declines, and is found by Miller, who returns him to Washington with the hope of finding a cure.
O'Malley tells the nation that his friend, a doctor, has informed him of the existence of a vaccine.
Act FourScully, administering a vaccine to Einstein, travels to Mulder and Miller's location. After finding them at the 14th Street Bridge, she discovers that Mulder is too badly ill to survive without a stem cell transplant. Miller inquires as to how this will be possible, Scully states that it is William, their son, who will have to donate. As Scully and Miller discuss Mulder's prognosis, Mulder begins to succumb to the virus he has contracted. Suddenly, a beam of light shines down onto Miller, Scully, and Mulder, and a triangle-shaped UFO slowly descends and hovers above them.
The episode ends with Scully looking at the lights of the spacecraft, shining down directly onto her and her partners.
- This episode marks the first appearance of Annabeth Gish as Monica Reyes since "The Truth," and the first episode in which she appeared without Robert Patrick as John Doggett.
- Since Robert Patrick declined to return, the writers chose not to mention his character John Doggett in the episode. Chris Carter explained "We couldn’t use Robert, so we didn’t want to hearken to a character [who was not there]…we wanted to be mindful of all viewers. Her story actually diverged from his, many years ago, so it wasn’t [needed]." 
- The flashback showing Monica visiting the Smoking Man seems to retcon and downplay the seriousness of his burns he sustained in the original season finale "The Truth". Whereas this episode shows him with mere burns over his body which is sorted with the help of surgery, "The Truth" episode showed the Smoking Man being burned right down to his skeleton after being directly struck with a missile, with no way of him being able to survive such an attack.
- David Duchovny as Special Agent Fox Mulder
- Gillian Anderson as Special Agent Dana Scully
- Mitch Pileggi as Assistant Director Walter Skinner
- Joel McHale as Tad O'Malley
- Lauren Ambrose as Agent Einstein
- Robbie Amell as Agent Miller
- Julian D. Christopher as Dr. Oscar Griffiths
- Annabeth Gish as Monica Reyes
- William B. Davis as Cigarette Smoking Man
- Aliza Vellani as Nurse Sandeep
- Sandy Da Costa as Morphing Alien
- Mik Byskov as Accosting Man
- Darren Dolynski as Man in Suit
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