Homer Simpson is the lead character in the animated series The Simpsons.

In 1995, Fox Mulder remarked that Owen Lee Jarvis looked like Homer Simpson's evil twin. (TXF: "Revelations")

In 1998, Gibson Praise watched a scene from The Simpsons involving Homer. (TXF: "The End")

The character of Homer from "The Beginning" was loosely based on Homer Simpson. Similar to Simpson, he was portrayed as lazy and worked at a nuclear power plant.
X-Files leads Mulder and Scully met Homer Simpson in an episode of The Simpsons, entitled "The Springfield Files". In the episode, the FBI agents investigated a claim made by Homer Simpson that he had seen an alien and discovered that the creature was actually regular character Mr. Burns, an elderly human.

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