- In real life, Donald Trump won the presidential election in November 2016, and was inaugurated in January 2017. A photo of the inuguration is seen in the opening of "My Struggle III", even though the episode should still be set in early 2016 as it immediately follows "My Struggle II", at which point Barack Obama was still president.
- In "The Lost Art of Forehead Sweat", an alien desired to build a wall around the Solar System, a jab at Donald Trump's well known plans to build a big wall around the Mexican border.
- The President that appears in the flash game The X-Files: Deep State bears a resemblance to Donald Trump. At the time that the game takes place (2010), Barack Obama was the president.
- The X-Files:
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