The Church of God with Signs & Wonders was a Pentecostal Fundamentalist Christian church near Blessing, Tennessee. It was run by Enoch O'Connor, a fiery reverend who practiced snake handling as a means of professing faith based on Jesus' words: "These signs will accompany those who have believed: in my name they will cast out demons, they will speak with new tongues; they will pick up serpents, and if they drink any deadly poison, it will not hurt them; they will lay hands on the sick, and they will recover." (see gospel of Mark 16:17,18). His daughter, Gracie O'Connor, and Jared Chirp were parishioners until the malicious affair with Samuel Mackey. Mackey impregnated Gracie with snakes in an effort to destroy Enoch's church and nearly succeeded, had it not been for the intervention of Mulder and Scully. (TXF: "Signs and Wonders")

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