1969 is a year in the 20th century.
- July: Apollo 11 reaches the moon, making it the first known manned space vehicle to reach the surface. (TXF: "Tempus Fugit"; "Alone")
- August 3: Three-year-old Sarah Lynn Graves drowns in her family's pool after her father, Howard Graves, forgets to latch the pool gate. (TXF: "Shadows")
- President Richard Nixon dismantles all United States bioweapons programs. (TXF: "The Pine Bluff Variant")
- Walter Skinner was serving as a U.S. Marine in South Vietnam admist the war there.
- One of John Lee Roche's victims was determined to have been killed sometime between this year and 1974, based on a dye analysis of the last "paper heart" found. (TXF: "Paper Hearts")